This study presents the first end-to-end Earthquake Early Warning system designed specifically for Italy’s high-speed railway. It details the full implementation process, demonstrating the technical and operational complexities of integrating real-time seismic alerts with rigid railway control interfaces capable of triggering automatic emergency braking. The successful pilot application has led the Italian railway company (Rete Ferroviaria Italiana, RFI) to prepare for expansion of this system to additional high-speed rail segments across the national network.