In this study, probabilistic tsunami hazard analysis was performed for the Tuzla region in case of a Prince Island fault rupture, which is the closest fault zone to the megacity Istanbul, and it has been silent for centuries. A synthetic earthquake catalog is generated using Monte Carlo simulations, and these events are used for tsunami analysis. The results of the study show that the probability of exceedance of 0.3 m tsunami wave height is bigger than 90 % for the next 50 and 100 years.