The manuscript offers significant contributions that justify its consideration as a highlight paper: It presents a novel, multifaceted methodology for identifying and compiling single hazard types and multi-hazard interrelationships in data-scarce urban settings, which is applied in the context of Kathmandu Valley, Nepal. The research provides a comprehensive database of 21 single hazard types and 83 multi-hazard interrelationships, contributing critical insights for disaster risk reduction (DRR) in “Global South” urban areas, with an emphasis on inclusive, people-centred approaches. By integrating stakeholder perspectives and multi-hazard scenario generation, the paper advances the development of dynamic risk scenarios, strengthening multi-hazard approaches for disaster preparedness and response.