The aim of the paper is the application of the KULTURisk regional risk assessment (KR-RRA) methodology, presented in the companion paper (Part 1), to the Sihl River basin, in northern Switzerland. Flood-related risks have been assessed for different receptors lying in the Sihl river valley including the city of Zurich, which represents a typical case of river flooding in an urban area, by means of a calibration process of the methodology to the site-specific context and features.