The study establishes the first local reference frame for the Gulf of Mexico region using the observations from 13 GNSS sites. The root mean square (RMS) of the velocities of the 13 reference stations achieves 0.2 mm yr⁻¹ in the horizontal and 0.3 mm yr⁻¹ in the vertical directions. Land subsidence, faulting, and salt dome activities in the Houston region, Mexico City, and the southeastern Louisiana region are discussed and compared.